PGD FOR IVF- A Technology For Fertility Purposes

Introduction

In today's technological world, reproductive technology has been invented and that is a preimplantation genetic diagnosis or short-named as PGD. It is applied with the cycle of IVF fertilization in order to amplify the potential for a successful pregnancy and delivery. Preimplantation genetic testing can be easily understood as a genetic test on cells abolished from the embryos, to facilitate in preferring the finest embryo to attain pregnancy or to keep away from a genetic ailment for which a couple is at risk.

The process of this reproductive technology can be considered in almost all cycles of IVF. That's why it is said as PGD for IVF. Those who can benefit themselves by this procedure are those couples who have been under an augmented risk for particular chromosome abnormalities or genetic disorders. It holds women who experienced multiple or more miscarriages or those who contain prior pregnancies that have chromosome abnormalities. Talking about PGD with IVF, the mixture of genetic testing with normal physical appearance signifies towards the highest chances of achieving a healthy pregnancy.

By the time when one-fourth or even half of the chances are there to have a baby affected with a specific genetic disease, PGD can be recommended in recognizing which embryo has been affected or unaffected for that disease. Then, the embryo that is affected due to the disease gets transmitted to the uterus to attempt the pregnancy that is also known as PGT-M.

PGD Cost In India

If someone wants to have PGD, its cost in India will be over 50,000 Rupees for the overall test. However, the cost can vary from a location as well as the success rates of the institution. But one must need to think about each and everything related to the test and it will be better to keep on researching about the best way to treat the problem.

PGD Testing

PGD testing takes place as a part of the IVF process. In this procedure, firstly medications will be given to the female patient for stimulating her ovaries to make multiple egg growths. When embryos get generated in the lab, a time of near about five to six days will be required in their growth. When the time reaches day five or six, and when the embryos arrive at the blastocyst stage, several cells that would become placental are eradicated from the outer layer of the embryo, called trophectoderm biopsy. Then the cells are transported to a special laboratory that will test for a specific abnormality with the help of some advanced techniques.

When the above process is done, the embryos are frozen with an instant effect with the process of vitrification. After getting the results returned, a usual embryo can be thawed and put back to the uterus in a subsequent frozen embryo cycle. Those embryos which haven't been affected by a chromosomal genetic abnormality, out of them, those which contains fine-quality get selected to transfer in the uterus. When the process is completed and there are more embryos remaining of good-quality and are unaffected, they can be remained cryopreserved for upcoming transfer of the embryo.

According to some information, it is explained that embryos have been historically biopsied on the third day of their development when nearly 6 to 8 embryos are there in the embryo. Recent literature has also suggested that biopsy can prove to be safer when the embryo is allowed to originate to the stage of the blastocyst at the fifth day or after that when the embryo has 200 or more cells.

PGD Success Rates

Talking about the success rates of PGD, there has been a data of many years which indicates that animals and different types of live births in humans imply that PGD doesn't hold increased birth defects over that of the universal population. An evaluation has been done where a child taking place in this world with the help of PGD doesn't demonstrate any evidence about the harmful effects of the process of growth and neurological development over the early years of life.

Embryos that hold both morphology and normal test results can be delivered in a frozen embryo transfer cycle. Morphology of embryo can prove to be supportive in choosing the best embryo to transfer. Many embryos that contain major chromosome abnormalities have normal morphology. Consequently, PGD results can help in recognizing the best embryo to transfer in the uterus for achieving a successful pregnancy.